![]() This condition can be harmless and resolve with time, or point to a more serious health problem. These include wearing a helmet and seatbelt when appropriate and removing trip hazards from your home and yard. People diagnosed with anisocoria have uneven pupil sizes. However, you can follow safety steps to prevent head injury, a common cause of anisocoria. Some cases of anisocoria cannot be prevented. Medications that may cause uneven pupils include glaucoma eye drops and certain types of anxiety medications and antidepressants. For example, possible causes include: direct trauma to the eye. This type develops as a side effect of medications. Anisocoria can result from a variety of things. This could be from optical surgery complications, injury or angle-closure glaucoma. Anisocoria, also called Adies tonic pupil or Adie syndrome, is described as uneven pupil size. This type develops after trauma to the eye that damages the iris. Horner syndrome can appear at any time of life in about 5 percent of affected individuals, the disorder is present from birth (congenital). This type is caused by an underlying disease or condition, including Horner’s syndrome, Adie’s tonic pupil and third nerve palsy. Description Horner syndrome is a disorder that affects the eye and surrounding tissues on one side of the face and results from paralysis of certain nerves. ![]() Most cases are benign and do not affect the pupils’ response to light. This is the most common type of anisocoria. However, having a large difference in pupil sizes that does not return to normal may indicate a serious health problem. Pupils fluctuate in size temporarily throughout the day, and there is usually nothing to worry about if they return to normal and additional symptoms aren’t present. A diameter difference of less than 0.5 millimeters is not uncommon. Many healthy people have different-sized pupils. Anisocoria is a condition characterized unequal pupil sizes.
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